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pentobarbital will lower the level or effect of etonogestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lessen the extent or result of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Double brexpiprazole dose in excess of one-two month